Warren JT, Guo Q, Tang WJ
A 1.3-A structure of zinc-bound N-terminal domain of calmodulin elucidates potential early ion-binding step.
J Mol Biol. 2007 Nov 23;374(2):517-27

Johnson EC, Malito E, Shen Y, Pentelute B, Rich D, Florián J, Tang WJ, Kent SB
Insights from atomic-resolution X-ray structures of chemically synthesized HIV-1 protease in complex with inhibitors.
J Mol Biol. 2007 Oct 26;373(3):573-86

Johnson EC, Malito E, Shen Y, Rich D, Tang WJ, Kent SB
Modular total chemical synthesis of a human immunodeficiency virus type 1 protease.
J Am Chem Soc. 2007 Sep 19;129(37):11480-90

Im, H, Manolopoulou, M, Malito, E, Shen, Y, Zhao, J, Neant-Fery, M, Sun, C-Y, Meredith, SC, Sisodia, SS, Leissring, M, and Tang, W-J
Structure of substrate-free human insulin degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE.
J Biol Chem. 2007 Aug 31;282(35):25453-63

Shen Y, Joachimiak A, Rosner MR, Tang WJ
Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
Nature. 2006 Oct 19;443(7113): 870-4

Guo Q, Shen Y, Lee YS, Gibbs CS, Mrksich M, Tang WJ
Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin.
EMBO J. 2005 Sep 21;24(18):3190-201.

Shen Y, Zhukovskaya NL, Guo Q, Florian J, Tang WJ
Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J. 2005 Mar 9;24(5):929-41.

Lee YS, Bergson P, He WS, Mrksich M, and Tang WJ
Discovery of a small molecule that inhibits the interaction of anthrax edema factor with its cellular activator, calmodulin.
Chem Biol. 2004 Aug;11(8):1139-46.

Guo, Q, Shen YQ, Zhukovskaya NL, Florian J, and Tang, WJ
Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products, cAMP and pyrophosphate.
J Biol Chem. 2004 Jul 9;279(28):29427-35.

Shen, YQ, Zhukovskaya NL, Zimmer MI, Soelaiman S, Wang CR, Gibbs CS, Tang WJ
Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection.
Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3242-7.

Soelaiman S, Wei B, Bergson P, Lee YS, Shen Y, Mrksich M, Shoichet B, Tang WJ
Structure-based inhibitor discovery against anthrax adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough
J Biol Chem. 2003 Jul 11;278(28):25990-7.

Ulmer T, Soelaiman S, Li S, Klee CB, Tang WJ, and Bax, A
Calcium-dependence of the anthrax edema factor calmodulin interaction
J Biol Chem. 2003 Aug 1;278(31):29261-6.

Shen YQ, Lee YS, Soelaiman S, Bergson P, Lu D, Chen A, Beckingham K, Grabarek Z, Mrksich M, Tang WJ
Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins
EMBO J. 2002 Dec 16;21(24):6721-32.

Drum CL, Yan SZ, Bard J, Shen YQ, Lu D, Soelaiman S, Grabarek Z, Bohm A, and Tang WJ
Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin
Nature. 2002 Jan 24;415(6870):396-402.

Yan SZ, Beeler J, Chen Y, Shelton RK, and Tang WJ
The regulation of human type 7 adenylyl cyclase by C1b and E. coli peptidyl prolyl isomerase, SlyD
J Biol Chem. 2001 Mar 16;276(11):8500-6.

Drum CL, Yan SZ, Sarac R, Mabuchi Y, Beckingham K, Bohm A, Grabarek Z, and Tang WJ
An extended conformation of calmodulin induces interactions between the structural domains of adenylyl cyclase from Bacillus anthracis to promote catalysis
J Biol Chem. 2000 Nov 17;275(46):36334-40.

Yan SZ, Huang ZH, Andrews RK, and Tang WJ
Conversion of forskolin insensitive to sensitive (mouse type IX) adenylyl cyclase
Mol Pharmacol. 1998 Feb;53(2):182-7.

Tang, WJ, and Hurley JH
Catalytic mechanism and regulation of mammalian adenylyl cyclases
Mol Pharmacol. 1998 Aug;54(2):231-40. Review.

Yan SZ, Huang ZH, Shaw R.S, and Tang WJ
The conserved aspargine and arginine are crucial for catalysis of mammalian adenylylcyclase
J Biol Chem. 1997 May 9;272(19):12342-9.

Yan SZ, Huang ZH, Rao VD, Hurley JH, and Tang WJ
Three discrete regions of mammalian adenylyl cyclase form a site for Gs-alpha activation.
J Biol Chem. 1997 Jul 25;272(30):18849-54.

Yan SZ, Hahn D, Huang ZH, and Tang WJ
Two cytoplasmic domains of mammalian adenylyl cyclase form a Gsa and forskolin-activated enzyme in vitro
J Biol Chem. 1996 May 3;271(18):10941-5.

Tang WJ and Gilman AG
Construction of a soluble adenylyl cyclase activated by Gs alpha and forskolin
Science. 1995 Jun 23;268(5218):1769-72.

Tang WJ, Stanzel M, and Gilman AG
Truncation and alanine-scanning mutants of type I adenylyl cyclase
Biochemistry. 1995 Nov 7;34(44):14563-72.

Tang WJ, Krupinski J, and Gilman AG
Expression and characterization of calmodulin activated (type I) adenylyl cyclase
J Biol Chem. 1991 May 5;266(13):8595-603.

Tang WJ and Gilman AG
Type-specific regulation of adenylyl cyclase by G protein bgsubunits
Science. 1991 Dec 6;254(5037):1500-3.